Layer properly: base layer wicks sweat, mid layer insulates, outer layer blocks wind. Heated grips or gloves are essential below 40F. Wind protection from fairing and handguards helps significantly.
Absolutely for regular winter riding. Cold hands are dangerous - they reduce grip strength and reaction time. Heated gloves ($150-300) maintain dexterity in temperatures that would numb regular gloves.
Most riders draw the line at 32F (freezing) due to ice risk. With proper gear, riding at 40-50F is comfortable. Below 40F requires dedicated winter gear or heated equipment.